Article

SC-BIG: A Hierarchical Bayesian Model for Bulk-Informed Single Nucleotide Variant Calling in Single Cells

2026-03-16

Abstract excerpt

Single-cell DNA sequencing (scDNA-seq) has emerged as a primary method for studying the evolution of cancer genomes and intra-tumor heterogeneity. However, despite technological advances, scDNA-seq remains noisy and is affected by amplification biases and allelic dropouts. Accurately determining the presence or absence of candidate somatic nucleotide variants (SNVs) in individual cancer cells therefore remains cha...

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Literature Corpus work: 210d0cc6-4c42-522e-8038-a5e9a724e3f3
DOI: 10.64898/2026.03.12.705671

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