Article

Inferring active mutational processes in cancer using single cell sequencing and evolutionary constraints

2025-02-27

Abstract excerpt

Ongoing mutagenesis in cancer drives genetic diversity throughout the natural history of cancers. As the activities of mutational processes are dynamic throughout evolution, distinguishing the mutational signatures of ‘active’ and ‘historical’ processes has important implications for studying how tumors evolve. This can aid in understanding mutagenic states at the time of presentation, and in associating active mu...

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Literature Corpus work: 99f729e8-78cd-58c5-a2d1-cfb498a3c287
DOI: 10.1101/2025.02.24.639589

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