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Article

Fast and scalable inference of multi-sample cancer lineages.

Genome biology - 6 May 2015

Popic Victoria, Salari Raheleh, Hajirasouliha Iman, Kashef-Haghighi Dorna, West Robert B, Batzoglou Serafim

Abstract excerpt

Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference for Cancer Heterogeneity and Evolution), a novel method that automates the phylogenetic inference of cancer...

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PMID: 25944252
DOI: 10.1186/s13059-015-0647-8
PMCID: PMC4501097

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