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<i>BiTSC</i> 2: Bayesian inference of tumor clonal tree by joint analysis of single-cell SNV and CNA data

25 Feb 2022

Abstract excerpt

The rapid development of single-cell DNA sequencing (scDNA-seq) technology has greatly enhanced the resolution of tumor cell profiling, providing an unprecedented perspective in characterizing intra-tumoral heterogeneity and understanding tumor progression and metastasis. However, prominent algorithms for constructing tumor phylogeny based on scDNA-seq data usually only take single nucleotide variations (SNVs) as...

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PMID: 35368055
DOI: 10.1093/bib/bbac092

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