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Evolutionary signatures of human cancers revealed via genomic analysis of over 35,000 patients

25 Sept 2023

Abstract excerpt

Recurring sequences of genomic alterations occurring across patients can highlight repeated evolutionary processes with significant implications for predicting cancer progression. Leveraging the ever-increasing availability of cancer omics data, here we unveil cancer's evolutionary signatures tied to distinct disease outcomes, representing "favored trajectories" of acquisition of driver mutations detected in...

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PMID: 37749078
DOI: 10.1038/s41467-023-41670-3

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