Article

SIEVE: joint inference of single-nucleotide variants and cell phylogeny from single-cell DNA sequencing data

2022-03-27

Abstract excerpt

Single-cell DNA sequencing (scDNA-seq) has enabled the identification of single nucleotide somatic variants and the reconstruction of cell phylogenies. However, statistical phylogenetic models for cell phylogeny reconstruction from raw sequencing data are still in their infancy. Here we present SIEVE (SIngle-cell EVolution Explorer), a statistical method for the joint inference of somatic variants and cell phyloge...

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Literature Corpus work: 9f450907-e4cd-529b-9087-043a87bc9f00
DOI: 10.1101/2022.03.24.485657

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