Article

A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

2023-11-01

Abstract excerpt

Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood. In this study, we identify signaling through Stimulator of Interferon Genes (STING) as an activator of LRRK2 via the Conjugation of ATG8 to Single Membranes (CASM...

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Literature Corpus work: 6fbcf4d9-2071-5ffb-bfa0-48ce8f9ff6b1
DOI: 10.1101/2023.10.31.564602

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