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The interplay between autophagy and cGAS-STING signaling and its implications for cancer

10 Apr 2024

Abstract excerpt

Autophagy is an intracellular process that targets various cargos for degradation, including members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double-stranded DNA and triggers an innate immune response through type I interferons. Emerging evidence suggests that autophagy plays a crucial role in regulating and fine-tuning cGAS-STING signaling. Reciprocally, cGAS-STING pathway members can...

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PMID: 38660307
DOI: 10.3389/fimmu.2024.1356369

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