Article

Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system

2018-01-01

Abstract excerpt

Leucine rich repeat kinase 2 (LRRK2) is a 286 kDa protein expressed in a variety of tissues and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 expression is induced by innate immune stimuli, and can be phosphorylated by Myd88 directed TLR signalling. Functional...

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Literature Corpus work: 0446cbf5-7b45-570b-9a59-e6270fe8063e
DOI: 10.17863/cam.20803

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