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Article

TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

6 Jul 2023

Abstract excerpt

Cells use noncanonical autophagy, also called conjugation of ATG8 to single membranes (CASM), to label damaged intracellular compartments with ubiquitin-like ATG8 family proteins in order to signal danger caused by pathogens or toxic compounds. CASM relies on E3 complexes to sense membrane damage, but so far, only the mechanism to activate ATG16L1-containing E3 complexes, associated with proton gradient loss, has...

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PMID: 37409525
DOI: 10.15252/embj.2022113105

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