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Article

LRRK2 in Infection: Friend or Foe?

27 Mar 2019

Abstract excerpt

In the field of Parkinson's disease (PD) research, leucine-rich repeat kinase 2 (LRRK2) remains one of the most enigmatic kinases. LRRK2 pathogenic mutations result in increased kinase activity, making LRRK2 an attractive therapeutic target for PD. For over 10 years, the identification of a bona fide substrate and a physiological function for LRRK2 has been elusive, and only recently, Rab GTPases were identified...

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PMID: 30915830
DOI: 10.1021/acsinfecdis.9b00051

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