Article

LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia

2024-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Mounting evidence supports a critical role for central nervous system (CNS) glial cells in neuroinflammation and neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), as well as neurovascular ischemic stroke. Previously, we found that loss of the PD-associated gene leucine-rich repeat kinase 2 ( Lrrk2 ) in macrophages, peripheral inna...

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Literature Corpus work: 39547ea0-b100-5ff5-b98e-f44773c92f90
DOI: 10.1101/2024.07.09.602769

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