Article

LRRK2 is activated by phosphatidylinositol 3-phosphate in conjunction with CASM

2025-12-18

Abstract excerpt

LRRK2 is a Parkinson’s disease (PD)-associated kinase that phosphorylates Rab GTPases. Hyperactivation of LRRK2, which is thought to cause PD, occurs on stressed endolysosomal membranes via CASM (conjugation of ATG8 to single membranes) and Rab, whereas the involvement of specific membrane lipids remained unclear. Here, we found that LRRK2 was potently activated upon treatment with PIKfyve inhibitors that increase...

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Identifiers and source

Literature Corpus work: 86c90f53-3469-5397-9cfc-217cb115aba6
DOI: 10.64898/2025.12.16.694573

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