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Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics

2021-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) provide a powerful means to identify loci and genes contributing to disease, but in many cases the related cell types/states through which genes confer disease risk remain unknown. Deciphering such relationships is important for identifying pathogenic processes and developing therapeutics. Here, we introduce sc-linker, a framework for integrating single-cel...

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Literature Corpus work: 37975de6-f272-543e-86d6-c8efdf8a7c10
DOI: 10.1101/2021.03.19.436212

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