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Article

Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity.

Frontiers in immunology - 1 Jan 2024

Townsend Hope A, Rosenberger Kaylee J, Vanderlinden Lauren A, Inamo Jun, Zhang Fan

Abstract excerpt

Background: Understanding genetic underpinnings of immune-mediated inflammatory diseases is crucial to improve treatments. Single-cell RNA sequencing (scRNA-seq) identifies cell states expanded in disease, but often overlooks genetic causality due to cost and small genotyping cohorts. Conversely, large genome-wide association studies (GWAS) are commonly accessible. Methods: We present a 3-step robust benchmarking...

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Identifiers

PMID: 39703500
DOI: 10.3389/fimmu.2024.1454263
PMCID: PMC11655331

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