Article

Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq

2026-08-23

Abstract excerpt

Integrating single-cell RNA-sequencing (scRNA-seq) with genome-wide association studies (GWAS) has shown promise in identifying critical cell types, states, and individual cells underlying heritable diseases. However, existing methods struggle to distinguish cell populations with correlated expression profiles but distinct functions, such as different T cell states or neuronal populations across brain regions, lea...

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Literature Corpus work: d3b009c9-7e22-5c4f-9484-a56d457f9051
DOI: 10.64898/2026.08.20.26360914

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