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sc2GWAS: a comprehensive platform linking single cell and GWAS traits of human.

Nucleic acids research - 6 Jan 2025

Yin Mingxue, Feng Chenchen, Yu Zhengmin, Zhang Yuexin, Li Ye, Wang Xuan, Song Chao, Guo Maozu, Li Chunquan

Abstract excerpt

Identifying cell populations associated with risk variants is essential for uncovering cell-specific mechanisms that drive disease development and progression. Integrating genome-wide association studies (GWAS) with single-cell RNA sequencing (scRNA-seq) has become an effective strategy for detecting trait-cell relationships. The accumulation of trait-related single cell data has led to an urgent need for its...

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PMID: 39565208
DOI: 10.1093/nar/gkae1008
PMCID: PMC11701642

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