Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts.

Cell genomics - 14 Jan 2026

Mu Zepeng, Randolph Haley E, Aguirre-Gamboa Raúl, Ketter Ellen, Dumaine Anne, Locher Veronica, Brandolino Cary, Liu Xuanyao, Kaufmann Daniel E, Barreiro Luis B, Li Yang I

Abstract excerpt

Only one-third of immune-associated genome-wide association study (GWAS) loci colocalize with expression quantitative trait loci (eQTLs), leaving most mechanisms unresolved. To address this, we created a unified single-cell chromatin accessibility (scATAC) map of ∼280,000 peripheral immune cells from 48 individuals, including 20 COVID-19 patients. Topic modeling of scATAC data identified continuous cell states...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to SARS-CoV-2

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41218612
DOI: 10.1016/j.xgen.2025.101061
PMCID: PMC12926193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts.PMID 41218612Read ↗

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contextsSemantic proximity Read ↗

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease riskSemantic proximity Read ↗

Connecting polygenic disease risk to cell states and regulatory programs through single-cell chromatin accessibilitySemantic proximity Read ↗

Population-scale multiome immune cell atlas reveals complex disease driversSemantic proximity Read ↗

Chromatin accessibility variation provides insights into missing regulation underlying immune-mediated diseasesSemantic proximity Read ↗

Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune CellsSemantic proximity Read ↗

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read ↗

Cell-specific regulatory circuits connect genetic variation to disease susceptibilitySemantic proximity Read ↗

Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune responseSemantic proximity Read ↗

Impact of cell-type and context-dependent regulatory variants on human immune traitsSemantic proximity Read ↗

High-resolution DNA accessibility profiles increase the discovery and interpretability of genetic associationsSemantic proximity Read ↗

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.