Article

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

2021-10-05

Abstract excerpt

<title>Abstract</title> <p>Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we introduce single-cell Disease Relevance Score (scDRS), an approach that links scRNA-seq with polygenic risk of disease at individual cell resolution; scDRS identifies...

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Literature Corpus work: 0cdf6cdc-9895-5f72-a0ec-dea3a56bbc17
DOI: 10.21203/rs.3.rs-933790/v1

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