Article

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

2021-09-28

Abstract excerpt

<h4>ABSTRACT</h4> Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we introduce single-cell Disease Relevance Score ( scDRS ), an approach that links scRNA-seq with polygenic risk of disease at individual cell resolution without the need for ann...

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Literature Corpus work: d8537df3-f4a9-5aba-8b33-6ae1d97ebed9
DOI: 10.1101/2021.09.24.461597

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