Article

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts

2024-12-12

Abstract excerpt

Only a third of immune-associated loci from genome-wide association studies (GWAS) colocalize with expression quantitative trait loci (eQTLs). To learn about causal genes and mechanisms at the remaining loci, we created a unified single-cell chromatin accessibility (scATAC-seq) map in peripheral blood comprising a total of 282,424 cells from 48 individuals. Clustering and topic modeling of scATAC data identified d...

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Literature Corpus work: f9c01e4f-0d12-5068-92ff-4240ea342a93
DOI: 10.1101/2024.12.05.24318552

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