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Synergistic effects of <i>APOE</i> ε4 and Alzheimer’s pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults

2025-06-25

Abstract excerpt

Amyloid-β (Aβ) and tau pathology begin accumulating decades before clinical symptoms and are influenced by APOE ε4, a key genetic risk factor for Alzheimer’s disease (AD). Although the presence of Aβ, tau, and APOE ε4 are thought to impact brain function, their effects on the neural correlates of episodic memory retrieval in preclinical AD remains unknown. We investigated this question in 159 cognitively unimpai...

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Literature Corpus work
6fa18e75-a1d6-5932-a7d9-d89009cc4eb3
DOI
10.1101/2025.06.20.660774
Open publication

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Synergistic effects of <i>APOE</i> ε4 and Alzheimer’s pathology on the neural correlates of episodic remembering in cognitively unimpaired older adultsDOI 10.1101/2025.06.20.660774
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