Article

APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline

2024-12-24

Abstract excerpt

Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). Individuals with one copy of APOE4 exhibit greater amyloid-beta (Aβ) deposition compared to noncarriers, an effect that is even more pronounced in APOE4 homozygotes. Interestingly, APOE4 carriers not only show more AD pathology but also experience more rapid cognitive decline, particularly in episodic memory. The...

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Literature Corpus work: 9a989188-03fb-5a3a-b268-bfa1580a52b9
DOI: 10.1101/2024.12.23.630203

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