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Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older <i>APOE4</i> carriers

2024-07-22

Abstract excerpt

The precuneus is an early site of amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer’s disease (AD) risk stages are lacking and the interaction with Apolipoprotein-E ( APOE ) genotype is unclear. In the PREVENT-AD cohort, we assessed how precuneus a...

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Literature Corpus work
bf9ce872-7daa-5071-a34d-7d1c6a615a04
DOI
10.1101/2024.07.18.604145
Open publication

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