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Article

Time Course and Severity of Cognitive Changes as a Function of Aβ Positivity and APOE Genotype in Alzheimer Disease.

Neurology - 22 Jul 2025

Vanderlip Casey R, Stark Craig E L

Abstract excerpt

BACKGROUND AND OBJECTIVES: APOE4 is the strongest genetic risk factor of sporadic Alzheimer disease (AD), associated with greater β-amyloid (Aβ) deposition and accelerated cognitive decline, especially in episodic memory. However, it remains unclear whether this decline is driven by increased Aβ burden in APOE4 carriers or by greater susceptibility to Aβ-related effects. In this study, we examined whether the...

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Identifiers

PMID: 40577676
DOI: 10.1212/WNL.0000000000213853
PMCID: PMC12205744

Genes

APOE

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