Article

APOE and amyloid-tau pathology in cognitively unimpaired older adults

2026-06-03

Abstract excerpt

<h4>INTRODUCTION</h4> APOE genotype shows well-established dose-dependent associations with higher amyloid in cognitively unimpaired (CU) adults. In contrast, associations with tau burden and cognition are less well characterized. <h4>METHODS</h4> We performed a cross-sectional analysis of harmonized multi-cohort ADSP-PHC data from 4,380 CU participants across 4 cohorts with APOE genotype, amyloid PET, and cogni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd2517de-2ee0-5fbc-92fc-b10bb8dda5fa
DOI: 10.64898/2026.06.02.26354753

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOE and amyloid-tau pathology in cognitively unimpaired older adultsDOI 10.64898/2026.06.02.26354753Read

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individualsSemantic proximity Read

Differences in AD-related pathology profiles across APOE groupsSemantic proximity Read

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals.Semantic proximity Read

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.Semantic proximity Read

Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.Semantic proximity Read

APOE interacts with tau PET to influence memory independently of amyloid PETSemantic proximity Read

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.Semantic proximity Read

Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment.Semantic proximity Read

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)Semantic proximity Read

APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory DeclineSemantic proximity Read

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele.Semantic proximity Read

Time Course and Severity of Cognitive Changes as a Function of Aβ Positivity and APOE Genotype in Alzheimer Disease.Semantic proximity Read