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Article

APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease.

Neurobiology of aging - 1 Mar 2015

Lim Yen Ying, Villemagne Victor L, Pietrzak Robert H, Ames David, Ellis Kathryn A, Harrington Karra, Snyder Peter J, Martins Ralph N, Masters Colin L, Rowe Christopher C, Maruff Paul

Abstract excerpt

The apolipoprotein E (APOE) ɛ4 allele and high levels of beta-amyloid (Aβ) are associated with episodic memory decline and risk for Alzheimer's disease. However, there is debate about independent or interactive effects of ɛ4 on Aβ-related memory decline in healthy older adults. Healthy older adults with high Aβ burden (n = 84) enrolled in Australian Imaging, Biomarkers, and Lifestyle Study were included in this...

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Source

Identifiers

PMID: 25559335
DOI: 10.1016/j.neurobiolaging.2014.12.008

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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