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Article

APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory.

Neurology - 25 Feb 2014

Kerchner Geoffrey A, Berdnik Daniela, Shen Jadon C, Bernstein Jeffrey D, Fenesy Michelle C, Deutsch Gayle K, Wyss-Coray Tony, Rutt Brian K

Abstract excerpt

OBJECTIVES: Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory. METHODS: Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, and 14 age-matched healthy controls with no group differences in APOE ε4 carrier status. Each...

Topics

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Alleles
Alzheimer Disease
Apolipoprotein E4
Atrophy
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Memory, Episodic

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Open in PubMed Open full text

Identifiers

PMID: 24453080
DOI: 10.1212/WNL.0000000000000154
PMCID: PMC3945665

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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