Article

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

2021-07-06

Abstract excerpt

Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across different conditions. It has been shown that this insight is critical for developing new therapies. In this regard, the role of individual genes in disease-relevant mechanisms can be hypothesized with transcri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f76216b-be39-5a72-b7db-4086f3fb6167
DOI: 10.1101/2021.07.05.450786

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanismsDOI 10.1101/2021.07.05.450786Read

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traitsSemantic proximity Read

Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traitsSemantic proximity Read

SIEVE: Locus-Anchored Drug Prioritization for Complex DisordersSemantic proximity Read

Phenome-Wide Association Studies: Embracing Complexity for Discovery.Semantic proximity Read

Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunitiesSemantic proximity Read

Predicting mechanism of action of cellular perturbations with pathway activity signaturesSemantic proximity Read

Multitrait genetic-phenotype associations to connect disease variants and biological mechanismsSemantic proximity Read

Applying the logic of genetic interaction to discover small molecules that functionally interact with human disease alleles.Semantic proximity Read

Exploring the omnigenic architecture of selected complex traits.Semantic proximity Read

Shared genetics across 178 phenotypes predicts novel drug therapeutic and side effectsSemantic proximity Read

Integrative signatures of signaling pathway response increase robustness and accuracy of pathway predictionsSemantic proximity Read

SEPARATING THE CAUSES AND CONSEQUENCES IN DISEASE TRANSCRIPTOME.Semantic proximity Read