Article

Predicting mechanism of action of cellular perturbations with pathway activity signatures

2019-07-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Motivation</h4> Misregulation of signaling pathway activity is etiologic for many human diseases, and modulating activity of signaling pathways is often the preferred therapeutic strategy. Understanding the mechanism of action (MOA) of bioactive chemicals in terms of targeted signaling pathways is the essential first step in evaluating their therapeutic potential. Changes in signaling pathw...

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Literature Corpus work: b7a86508-3a58-5035-974b-198b360a675a
DOI: 10.1101/705228

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