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Article

Exploring the omnigenic architecture of selected complex traits.

American journal of human genetics - 4 Sept 2025

Ratajczak Florin, Heinig Matthias, Falter-Braun Pascal

Abstract excerpt

Genome-wide association studies (GWASs) have statistically identified thousands of loci influencing a trait of interest. To explain the organizational principles among the functionally often unrelated encoded proteins, the omnigenic model postulates core genes with direct and peripheral genes with indirect effects on molecular trait etiology. However, both core genes and the network paths by which they are...

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Identifiers

PMID: 40763733
DOI: 10.1016/j.ajhg.2025.07.006
PMCID: PMC12461020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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