Article

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

2019-01-28

Abstract excerpt

Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating epigenome data to estimate the functional importance of genetic variation on gene expression, we improve the accuracy of transcriptome prediction and the power to detect significant expression-trait associations. Joint analysis of 14 large-scale transcriptome datase...

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Literature Corpus work: c3acd033-cfc4-5072-8376-2a46223a5f7f
DOI: 10.1101/532929

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