Article

Shared genetics across 178 phenotypes predicts novel drug therapeutic and side effects

2025-05-13

Abstract excerpt

Human genetics holds great potential for drug discovery, but challenges in identifying causal genes limit its clinical translation. Pleiotropy, the phenomenon where genetic variants or genes influence multiple traits, has been previously used to explain clinical associations between diseases and propose drug repurposing opportunities. However, its potential to systematically inform drug discovery remains unknown....

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Literature Corpus work: 46372ff4-26d3-5dd3-9091-95006de47811
DOI: 10.1101/2025.05.13.25327511

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