Article

SIEVE: Locus-Anchored Drug Prioritization for Complex Disorders

2026-04-17

Abstract excerpt

<h4>Motivation</h4> Complex disorders arise from multiple genetic mechanisms, but most drug-prioritization methods treat each disorder as a single phenotype and therefore miss locus-specific therapeutic opportunities. <h4>Results</h4> We present SIEVE, a framework that decomposes complex disorders into genetically localized subphenotypes and links GWAS summary statistics, reference expression, and perturbational...

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Literature Corpus work: fcdc285b-6211-5ce6-b98d-274ac23cab14
DOI: 10.64898/2026.04.15.26350958

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