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Article

Applying the logic of genetic interaction to discover small molecules that functionally interact with human disease alleles.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Brettman Ari D, Tan Pauline H, Tran Khoa, Shaw Stanley Y

Abstract excerpt

Despite rapid advances in the genetics of complex human diseases, understanding the significance of human disease alleles remains a critical roadblock to clinical translation. Here, we present a chemical biology approach that uses perturbation with small molecules of known mechanism to reveal mechanistic and therapeutic consequences of human disease alleles. To maximize human applicability, we perform chemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25618333
DOI: 10.1007/978-1-4939-2269-7_2
PMCID: PMC4357233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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