Article

Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities

2018-09-25

Abstract excerpt

Genome-wide association studies (GWAS) have made considerable progress and there is emerging evidence that genetics-based targets can lead to 28% more launched drugs. However, translating the results of GWAS for drug discovery remains challenging. We analyzed 1,589 GWAS across 1,456 protein interaction pathways to translate these often, imprecise genetic loci into therapeutic hypotheses for 182 diseases. We valida...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1f81b1f-28bf-5485-bf57-afd9e42c8e63
DOI: 10.1101/425769

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunitiesDOI 10.1101/425769Read

Pathway and network-based strategies to translate genetic discoveries into effective therapiesSemantic proximity Read

Large scale analysis of phenotype-pathway relationships based on GWAS results.Semantic proximity Read

Gene and pathway-based second-wave analysis of genome-wide association studies.Semantic proximity Read

GWAS and drug targets.Semantic proximity Read

Pathway-based approaches for analysis of genomewide association studies.Semantic proximity Read

Network and pathway expansion of genetic disease associations identifies successful drug targets.Semantic proximity Read

Using genome-wide pathway analysis to unravel the etiology of complex diseases.Semantic proximity Read

Network and pathway expansion of genetic disease associations identifies successful drug targetsSemantic proximity Read

Multi-layered genetic approaches to identify approved drug targetsSemantic proximity Read

Advancing the use of genome-wide association studies for drug repurposing.Semantic proximity Read

Identifying disease related sub-pathways for analysis of genome-wide association studies.Semantic proximity Read

Pathway analysis for genome-wide genetic variation data: Analytic principles, latest developments, and new opportunities.Semantic proximity Read