Article

Integrative signatures of signaling pathway response increase robustness and accuracy of pathway predictions

2022-06-04

Abstract excerpt

<h4>Motivation</h4> Aberrant cell signaling is known to drive progression of cancer and many other diseases. The study of signaling pathways within cells is central to identifying drugs that seek to modulate these pathways. Expression of pathway genes (i.e. genes that code for pathway proteins) correlates poorly with signaling pathway activity, making prediction of signaling pathway activity changes based on tran...

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Literature Corpus work: 331fc8cd-5b0b-5dd2-bf56-0352ee00ce1b
DOI: 10.1101/2022.06.03.494712

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