Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenome-Wide Association Studies: Embracing Complexity for Discovery.

Human heredity - 1 Jan 2015

Pendergrass Sarah A, Verma Anurag, Okula Anna, Hall Molly A, Crawford Dana C, Ritchie Marylyn D

Abstract excerpt

The inherent complexity of biological systems can be leveraged for a greater understanding of the impact of genetic architecture on outcomes, traits, and pharmacological response. The genome-wide association study (GWAS) approach has well-developed methods and relatively straight-forward methodol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Environment
Share to Epistasis, Genetic
Share to Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 26201697
DOI: 10.1159/000381851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26201697-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenome-Wide Association Studies: Embracing Complexity for Discovery.PMID 26201697Read ↗

An integrative analysis of genomic and exposomic data for complex traits and phenotypic predictionSemantic proximity Read ↗

An integrative analysis of genomic and exposomic data for complex traits and phenotypic prediction.Semantic proximity Read ↗

Phenomics: expanding the role of clinical evaluation in genomic studies.Semantic proximity Read ↗

The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery.Semantic proximity Read ↗

Maturation and application of phenome-wide association studies.Semantic proximity Read ↗

Mapping the Analytical Landscape of Gene-Diet Interactions in Epidemiology: From Classical Models to Causal and Multi-Omics Frameworks.Semantic proximity Read ↗

Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.Semantic proximity Read ↗

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanismsSemantic proximity Read ↗

Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine.Semantic proximity Read ↗

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine.Semantic proximity Read ↗

Characterizing the genetic architecture of drug response using gene-context interaction methodsSemantic proximity Read ↗

Phenome-wide association studies: a new method for functional genomics in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.