Article

SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activation

2025-09-13

Abstract excerpt

Axon degeneration is a hallmark of nearly all neurodegenerative diseases. SARM1 plays a central role in this process by degrading NAD + into nicotinamide and ADPR or cADPR. SARM1 also catalyzes a base exchange reaction between NAD + -phosphate (NADP + ) and nicotinic acid (NA) to generate NAADP. These second messengers (i.e., ADPR, cADPR, and NAADP), and NAD + consumption, are thought to drive axon degeneratio...

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Literature Corpus work: 5d6332be-b349-5c65-910f-aeaec7ae86c3
DOI: 10.1101/2025.09.12.675907

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SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activationDOI 10.1101/2025.09.12.675907Read

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