Article

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

2019-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these proteins led to the identification of non-axotomy insults causing axon degeneration by a Wallerian-like mechanism, including several involving mitochondrial impairment. Mi...

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Literature Corpus work: 3d3fef17-e252-5cb0-bac8-c421c1814148
DOI: 10.1101/683342

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