NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.

doi:10.1038/s41467-019-13172-8

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Article

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.

Nature communications - 21 Nov 2019

Fang Evandro F, Hou Yujun, Lautrup Sofie, Jensen Martin Borch, Yang Beimeng, SenGupta Tanima, Caponio Domenica, Khezri Rojyar, Demarest Tyler G, Aman Yahyah, Figueroa David, Morevati Marya, Lee Ho-Joon, Kato Hisaya, Kassahun Henok, Lee Jong-Hyuk, Filippelli Deborah, Okur Mustafa Nazir, Mangerich Aswin, Croteau Deborah L, Maezawa Yoshiro, Lyssiotis Costas A, Tao Jun, Yokote Koutaro, Rusten Tor Erik, Mattson Mark P, Jasper Heinrich, Nilsen Hilde, Bohr Vilhelm A

Abstract excerpt

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic deficit can be targeted for therapeutic intervention has not been determined. Here we report impaired mitophagy and...

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Identifiers

PMID: 31754102
DOI: 10.1038/s41467-019-13172-8
PMCID: PMC6872719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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