Article

Nuclear NAD <sup>+</sup> -biosynthetic enzyme NMNAT1 facilitates survival of developing retinal neurons

2021-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD + homeostasis for health and function, the specific roles of subcellular NAD + pools in retinal development, maintenance, and disease remain obscure. Here, we show that deletion of the nuclear-localized NAD + synthase nicotinamide mononucleotide adenylyltransferase-1 (NMNAT1) in the developing murine re...

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Literature Corpus work: 37d230fe-54b1-501c-95d1-4768d1e914bb
DOI: 10.1101/2021.05.05.442836

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