Article

CopyMix: Mixture Model Based Single-Cell Clustering and Copy Number Profiling using Variational Inference

2020-01-31

Abstract excerpt

Investigating tumor heterogeneity using single-cell sequencing technologies is imperative to understand how tumors evolve since each cell subpopulation harbors a unique set of genomic features that yields a unique phenotype, which is bound to have clinical relevance. Clustering of cells based on copy number data obtained from single-cell DNA sequencing provides an opportunity to identify different tumor cell subpo...

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Literature Corpus work: 6f05f96b-213a-5f91-bf62-1f054b9bf040
DOI: 10.1101/2020.01.29.926022

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