Article

Mapping single-cell transcriptomes to copy number evolutionary trees

2021-11-05

Abstract excerpt

Cancer arises and evolves by the accumulation of somatic mutations that provide a selective advantage. The interplay of mutations and their functional consequences shape the evolutionary dynamics of tumors and contribute to different clinical outcomes. In the absence of scalable methods to jointly assay genomic and transcriptomic profiles of the same individual cell, the two data modalities are usually measured se...

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Literature Corpus work: c743dea5-1aa6-51b7-813e-f5b0050fcf4a
DOI: 10.1101/2021.11.04.467244

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