Article

Bayesian inference for copy number intra-tumoral heterogeneity from single-cell RNA-sequencing data

2023-10-25

Abstract excerpt

High-resolution molecular characterization of intra-tumoral clonal structure defined by genomic and epigenomic alterations is crucial in understanding the natural history of tumors and advancing cancer treatment strategies. Copy number alterations (CNA) are of notable importance as both drivers and markers of clonal structure that can now be assayed at individual cell resolution. However, specific computational me...

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Literature Corpus work: 6c1b5f30-9ef0-532e-acf1-d3ac37813f3f
DOI: 10.1101/2023.10.22.563455

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