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Article

SCOPE: A Normalization and Copy-Number Estimation Method for Single-Cell DNA Sequencing.

Cell systems - 20 May 2020

Wang Rujin, Lin Dan-Yu, Jiang Yuchao

Abstract excerpt

Whole-genome single-cell DNA sequencing (scDNA-seq) enables characterization of copy-number profiles at the cellular level. We propose SCOPE, a normalization and copy-number estimation method for the noisy scDNA-seq data. SCOPE's main features include the following: (1) a Poisson latent factor model for normalization, which borrows information across cells and regions to estimate bias, using in silico identified...

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Identifiers

PMID: 32437686
DOI: 10.1016/j.cels.2020.03.005
PMCID: PMC7250054

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