Article

Single-cell copy number calling and event history reconstruction

2020-04-30

Abstract excerpt

Copy number alterations are driving forces of tumour development and the emergence of intra-tumour heterogeneity. A comprehensive picture of these genomic aberrations is therefore essential for the development of personalised and precise cancer diagnostics and therapies. Single-cell sequencing offers the highest resolution for copy number profiling down to the level of individual cells. Recent high-throughput prot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f2367a8-59f0-5e88-8038-f7d2879066a6
DOI: 10.1101/2020.04.28.065755

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell copy number calling and event history reconstructionDOI 10.1101/2020.04.28.065755Read

CONET: copy number event tree model of evolutionary tumor history for single-cell dataSemantic proximity Read

SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distancesSemantic proximity Read

SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances.Semantic proximity Read

SCONCE: a method for profiling copy number alterations in cancer evolution using single-cell whole genome sequencingSemantic proximity Read

Bayesian inference for copy number intra-tumoral heterogeneity from single-cell RNA-sequencing dataSemantic proximity Read

Pharming: Joint Clonal Tree Reconstruction of Single-Nucleotide Variant and Copy Number Aberration Evolution from Single-Cell DNA Sequencing of Tumors.Semantic proximity Read

Methods for Copy Number Aberration Detection from Single-cell DNA Sequencing DataSemantic proximity Read

CopyMix: Mixture Model Based Single-Cell Clustering and Copy Number Profiling using Variational InferenceSemantic proximity Read

Assessing the performance of methods for copy number aberration detection from single-cell DNA sequencing data.Semantic proximity Read

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolutionSemantic proximity Read

A Bayesian method to cluster single-cell RNA sequencing data using Copy Number AlterationsSemantic proximity Read

Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL.Semantic proximity Read