Article
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation.
BMC genomics - 4 Nov 2012
Nilsen Gro, Liestøl Knut, Van Loo Peter, Moen Vollan Hans Kristian, Eide Marianne B, Rueda Oscar M, Chin Suet-Feung, Russell Roslin, Baumbusch Lars O, Caldas Carlos, Børresen-Dale Anne-Lise, Lingjaerde Ole Christian
Abstract excerpt
BACKGROUND: Cancer progression is associated with genomic instability and an accumulation of gains and losses of DNA. The growing variety of tools for measuring genomic copy numbers, including various types of array-CGH, SNP arrays and high-throughput sequencing, calls for a coherent framework offering unified and consistent handling of single- and multi-track segmentation problems. In addition, there is a demand...
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