Article
Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes.
Nature biotechnology - 1 May 2021
Gao Ruli, Bai Shanshan, Henderson Ying C, Lin Yiyun, Schalck Aislyn, Yan Yun, Kumar Tapsi, Hu Min, Sei Emi, Davis Alexander, Wang Fang, Shaitelman Simona F, Wang Jennifer Rui, Chen Ken, Moulder Stacy, Lai Stephen Y, Navin Nicholas E
Abstract excerpt
Single-cell transcriptomic analysis is widely used to study human tumors. However, it remains challenging to distinguish normal cell types in the tumor microenvironment from malignant cells and to resolve clonal substructure within the tumor. To address these challenges, we developed an integrative Bayesian segmentation approach called copy number karyotyping of aneuploid tumors (CopyKAT) to estimate genomic copy...
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