Article

Combination of Haloperidol with UNC9994, β-arrestin-biased analog of Aripiprazole, ameliorates schizophrenia-related phenotypes induced by NMDAR deficit in mice

2024-04-28

Abstract excerpt

<h4>Background</h4> Glutamatergic system dysfunction, particularly involving the N-methyl-D-aspartate receptor (NMDAR), contributes to a full spectrum of schizophrenia-like symptoms, including the cognitive and negative symptoms that are resistant to treatment with antipsychotic drugs (APDs). Aripiprazole, an atypical antipsychotic drug (APD), acts as a dopamine partial agonist and its combination with haloperido...

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Literature Corpus work: 6ed1c8f1-de39-5e61-80e3-93879f2979f6
DOI: 10.1101/2024.04.25.591166

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